Aprotinin , also known as bovine pancreatic trypsin inhibitor, BPTI (Trasylol, Bayer ) is a protein, that is used as medication administered by injection to reduce bleeding during complex surgery , such as heart and liver surgery. 更多

Aprotinin , also known as bovine pancreatic trypsin inhibitor, BPTI (Trasylol, Bayer ) is a protein, that is used as medication administered by injection to reduce bleeding during complex surgery , such as heart and liver surgery. Its main effect is the slowing down of fibrinolysis , the process that leads to the breakdown of blood clots. The aim in its use is to decrease the need for blood transfusions during surgery, as well as end-organ damage due to hypotension (low blood pressure) as a result of marked blood loss. The drug was temporarily withdrawn worldwide in 2007 after studies suggested that its use increased the risk of complications or death [ 1 ] ; after this was confirmed by follow-up studies, Trasylol was entirely and permanently withdrawn in May 2008, except - at least for the time being - for very restricted research use. less