Biperiden is an antiparkinsonian agent [ 1 ] of the anticholinergic type. [ 2 ] The original brand name, which still exists and is manufactured by BASF / Knoll Pharma is Akineton . Generics are available worldwide. 更多

Biperiden is an antiparkinsonian agent [ 1 ] of the anticholinergic type. [ 2 ] The original brand name, which still exists and is manufactured by BASF / Knoll Pharma is Akineton . Generics are available worldwide.

The oral bioavailability is only 33 +/- 5% due to extensive first-pass metabolization . In young, healthy volunteers peak plasma concentrations following an oral single dose of 4mg in immediate release form are reached after 1.5 hours. The elimination half-life has been determined as 18.4 hours, and may be prolonged in geriatric patients. After IV dosing of 4mg the elimination half-life is approximately 24 hours. less